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Experiments

Compound Investigated event Experiment type Concentration Cell line Organism Animal model Stat protein Details
Tofacitinib (CP-690.550) Influence on protein activity in presence of TGF-β and IL-6 Western Blot 10.00 nM Naïve CD4+ T Mus musculus c57BL/6 p-STAT3
Tofacitinib (CP-690.550) Influence on protein activity in presence of TGF-β and IL-6 Western Blot 30.00 nM Naïve CD4+ T Mus musculus c57BL/6 p-STAT3
Tofacitinib (CP-690.550) Influence on protein activity in presence of TGF-β and IL-6 Western Blot 100.00 nM Naïve CD4+ T Mus musculus c57BL/6 p-STAT3
Tofacitinib (CP-690.550) Influence on protein activity in presence of IL-6 Western Blot 30.00 nM Naïve CD4+ T Mus musculus c57BL/6 p-STAT3
Tofacitinib (CP-690.550) Influence on protein activity in presence of IL-6 Western Blot 100.00 nM Naïve CD4+ T Mus musculus c57BL/6 p-STAT3
Tofacitinib (CP-690.550) Influence on protein activity in presence of IL-6 Western Blot 300.00 nM Naïve CD4+ T Mus musculus c57BL/6 p-STAT3
Tofacitinib (CP-690.550) Influence on protein activity in transfecfected cells Western Blot 30.00 nM HEK293T Homo sapiens p-STAT3
Tofacitinib (CP-690.550) Influence on protein activity in transfecfected cells Western Blot 100.00 nM HEK293T Homo sapiens p-STAT3
Tofacitinib (CP-690.550) Influence on protein activity in transfecfected cells Western Blot 300.00 nM HEK293T Homo sapiens p-STAT3
Tofacitinib (CP-690.550) Influence on protein activity in transfecfected cells Western Blot 1000.00 nM HEK293T Homo sapiens p-STAT3
Tofacitinib (CP-690.550) Influence on protein acticity in presence of IL-6 Western Blot 30.00 nM FLS Homo sapiens p-STAT3
Tofacitinib (CP-690.550) Influence on protein acticity in presence of IL-6 Western Blot 100.00 nM FLS Homo sapiens p-STAT3
Tofacitinib (CP-690.550) Influence on protein acticity in presence of IL-6 Western Blot 300.00 nM FLS Homo sapiens p-STAT3
Tofacitinib (CP-690.550) Influence on protein acticity in presence of IL-6 Western Blot 1000.00 nM FLS Homo sapiens p-STAT3
Tofacitinib (CP-690.550) Influence on protein acticity in presence of TNF Western Blot 1000.00 nM FLS Homo sapiens p-STAT3
Tofacitinib (CP-690.550) Influence on protein activity in presence of TGF-β and IL-6 Western Blot 10.00 nM Naïve CD4+ T Mus musculus c57BL/6 STAT3
Tofacitinib (CP-690.550) Influence on protein activity in presence of TGF-β and IL-6 Western Blot 30.00 nM Naïve CD4+ T Mus musculus c57BL/6 STAT3
Tofacitinib (CP-690.550) Influence on protein activity in presence of TGF-β and IL-6 Western Blot 100.00 nM Naïve CD4+ T Mus musculus c57BL/6 STAT3
Tofacitinib (CP-690.550) Influence on protein activity in presence of IL-6 Western Blot 30.00 nM Naïve CD4+ T Mus musculus c57BL/6 STAT3
Tofacitinib (CP-690.550) Influence on protein activity in presence of IL-6 Western Blot 100.00 nM Naïve CD4+ T Mus musculus c57BL/6 STAT3
Tofacitinib (CP-690.550) Influence on protein activity in presence of IL-6 Western Blot 300.00 nM Naïve CD4+ T Mus musculus c57BL/6 STAT3
Tofacitinib (CP-690.550) Influence on protein acticity in presence of IL-6 Western Blot 30.00 nM FLS Homo sapiens STAT3
Tofacitinib (CP-690.550) Influence on protein acticity in presence of IL-6 Western Blot 100.00 nM FLS Homo sapiens STAT3
Tofacitinib (CP-690.550) Influence on protein acticity in presence of IL-6 Western Blot 300.00 nM FLS Homo sapiens STAT3
Tofacitinib (CP-690.550) Influence on protein acticity in presence of IL-6 Western Blot 1000.00 nM FLS Homo sapiens STAT3
Tofacitinib (CP-690.550) Influence on protein acticity in presence of TNF Western Blot 1000.00 nM FLS Homo sapiens STAT3